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Did-you-know ... ?
Contents:
Australians with multiple risk
factors for cardiovascular disease
Butter or Margarine
Cardiac
Resynchronization Therapy (CRT)
Child obesity
Cholesterol management -
Statins
Drug Eluting Stents (DES)
Heart Failure incidence and
prevalence
Identifiable causes of
AF
Metabolic Syndrome
Obstructive Sleep Apnoea
(OSA)
Reduce cardiac mortality by
27%!!!!
Risk of AMI
Smoking - Quiting smoking is
difficult
Time delay to treatment and mortlaity in AMI
Vascular grafts - Types of
Australians
with multiple risk factors for cardiovascular disease
*
Around nine in ten Australian adults had at least one risk
factor * Poor diet and physical inactivity were
the most prevalent risk factors * Regardless of age,
people were most likely to have two risk factors *
People in the most disadvantaged socioeconomic group were more likely to
have three or more risk factors * People who had
more risk factors were also more likely to report even having had a heart
attack, stroke, angina or atherosclerosis – independent of age and
sex
Ref: 2001 National Health
Survey
Atrial Fibrillation
Most common sustained cardiac
arrhythmia and a major cause of illness and death in our community It is a
major cause of hospital admissions. AF significantly increases risk for
stroke.
Prevalence: Less than 1% in
young adults, but approximately 10% in those aged 80 and
above
Butter or Margarine
The National Heart Foundation
recommends margarine or other vegetable oil spreads, while national
dietary guidelines recommend unsaturated margarines made from canola,
sunflower, safflower or olive oil. Even the best dairy blends contain more
saturated fat than other spreads. All margarines with the NHF tick have
been independently tested to ensure they have a maximum of just one
percent of total fat as trans fat. Buy a low-salt option whenever you
can. Whatever you choose, spread it sparingly and use vegetable or olive
oil rather than margarine or butter for frying.
Cardiac Resynchronization Therapy
(CRT)
is
indicated in patients stable on optimal medical therapy that
have:
- moderate
to severe heart failure (NYHA Class III-IV),
- QRS
>130ms and
- LV ejection
fraction <35%
CRT in randomized clinical
trials has been shown to:
- improve
quality of life and functional capacity, with persistence through 1
year,
- reduce
mortality and heart failure and
- improve
cardiac function and structure
Notes from Dr Bruno Martin,
Cabrini Conference, July, 2007
Child obesity
A report published in the
International Journal of Paediatric Obesity has found that obesity rates
in Australian children jumped from 4 per cent in 1901 to more than 30 per
cent in 2003. Professor Kevin Norton’s report took in data from 41 studies
since 1901 that weighed 500,000 Australian children aged five to 15.
The study also found that in 30 years’ time the number of overweight
or obese children will double, matching the current rate of adult obesity.
Australia has the fastest growing rate of childhood obesity in the
world
Cholesterol
management - Statins
- Decrease LDL by
approx 20-60%
- Decrease triglycerides
by approx 10-35%
- Increase HDL by approx
13%
- Majority of effect on
lipid sub-fractions seen with initiation dose
- Use may be
limited by adverse events - myopathy,
hepatotoxicity
References:
Approved Production Information for Lipitor,
MIMS Annual, 30th Ed, 2006, 2: 187-89
Approved Production Information for
ZOCOR, MIMS Annual, 30th Ed. 2006, 2: 201-04
Approved Production Information for LIPEX,
MIMS Annual, 30th Ed. 2006, 2: 182-86
Approved Production Information for
Pravachol, MIMS Annual, 30th Ed. 2006, 2:
192-95
Leilersdorf E et al. Eur Heart J 2001, 3
(supp) E 17-23
Drug Eluting
Stents (DES)
Challenges
in Percutaneous Coronary Intervention
Restenosis was
largely overcome by the
evolution of the drug-eluting stent (DES)
- Taxus
(Pacilitaxal)
- Cypher
(Sirolimus)
Second generation:
- Endeavor
(Zarolimus)
- Xience V
(Everolimus)
(late)Stent thrombosis is the new Achilles
Heel of the drug-eluting stents
In fact, the incidence of mortality or AMI
rates: 64.4% (angiographically proven ST)
In practice:
- Bare Metal Stent
(BMS): ASA + Clopidogrel - 1 month+ (1 year+ (if ACS)) ASA fo
life
- Drug-eluting
Stent (DES): ASA + Clopidogrel long term (12 months) ASA for
life
Notes from Dr David McGaw, Cardiologist,
Cabrini, July 2007
Heart Failure incidence and
prevalence
HF is the
major cause of mortality-morbidity and hospitalization in pts > 60
years
Costs represent 1 – 2% of the global health expenses ($10 –
38 billion/yr in the US)
HF patients
take an average of 6 medications
78% of
patients have had at least 2 admissions/year
Despite
major advances in medical therapy, morbidity and mortality remain high:
50% 5-year mortality for all heart failure grades, 50% 1-year mortality
for NYHA class 4
Notes from
Dr Meroula Richardson’s talk, Cabrini Conference, July
2007
Identifiable causes of
AF:
* Hypertension * Coronary Heart
Disease * Valvular Heart
Disease * Cardiomyopathy/CHF *
Pericarditis * Pulmonary
Embolism * Alcohol excess * No
identifiable cause - also known
as "lone AF": 2 - 30% -
?genetic
cause - get a good family
history!
Notes from
lecture by A/Professor Diane Fatkin, Molecular Cardiology,
Victor
Chang Cardiac
Research Institute, Sydney, NSW
Metabolic Syndrome
A
clustering of risk factors (hyperglycaemia, hypertension, hypertriglyceridaemia, low levels of high-density lipoprotein(HDL)
cholesterol, and overweight/obesity) identified as 'metabolic
syndrome" has gained
widespread recognition.
MetS
is strongly associated with an increased risk of Type 2 Diabetes and
CVD
According to the International Diabetes Federation criteria, 29.1%
of Australians over the age of 25 have metabolic syndrome
Ref:
Albert KG, Zimmet PZ, Shaw J. Metabolic Syndrome - a new world-wide
definition: A consensus statement from the International Diabetes
Federation, Diabet Med 2006; 23:
469-80
OBESITY
21% of adults
in low-income households are obese
15% of adults in
high-income households are obese
13% of adults with a
degree/diploma or higher are obese
- 5.4million (45%)
adults overweight or obese
- Average male weight:
80kg
- Average female weight:
65kg
- Men heaviest aged 45
to 54yrs
2004 - 2005:
- 7.5 million (54%)
adults overweight or obese
- Average male weight:
84kg
- Average female weight:
65kg
- Men heaviest aged 35 -
44yrs
Source: ABS Social Trends,
2007
Obstructive Sleep Apnoea
(OSA
)
Obstructive sleep apnoea (OSA)
has been clearly linked to accelerated cardiovascular disease and death.
The injurious mechanisms by which OSA leads to accelerated cardiovascular
disease and heart failure relate to: increased mechanical work, raised
sympathetic activity, hypoxia, coagulability and endothelial dysfunction.
These injurious effects of OSA include: hypertension in a dose dependent
manner; accelerated ischaemic heart disease, nocturnal and daytime
arrhythmias, vascular dysfunction and raised coagulability, and increased
incidence of stroke. These are independent of coexisting diabetes, obesity
and smoking history * 17% of all motor vehicle
accidents are related to OSA * 43cm collar size +
history of Hypertension = OSA Notes from Dr Peter Solin’s talk on OSA
and it’s relationship with cardiac disease Cabrini Conference, July
2007
Recommendations for device-based treatment of
symptomatic chronic heart failure(CHF)
Biventricular pacing (cardiac
resynchronisation therapy - CRT), with or without
implantable cardioverter defibrillator, should be considered in
patients with CHF who fulfil each of the following
criteria:
* NYHA symptoms
class iii-iv on treatment * Dilated heart failure
with LVEF <35% * QRS duration >
120ms * Sinus rhythm
(1)
Implantable cardioverter
defibrillator (ICD) implantation should be considered in
patients with CHF who fulfil any of the following criteria:
* Survived
cardiac arrest resulting from ventricular fibrillation or
ventricular tachycardiac not due to a
transient or reversible cause * Spontaneous
sustained VT in association with structural coronary heart
disease * LVEF
<30% measured at least 1 month after acute myocardial infarction
or 3 months after coronary artery
revascularisation surgery * Symptomatic CHF (NYHA
functional class ii-iii) and LVEF <35% (2)
References:
(1) Cazeau S et al Effects of
multisite biventricular pacing in patients
with heart failure and
intraventricular conduction delay. N Eng J Med 2001;
344: 873-880
Reduce
cardiac mortality by 27%!!!!
“If there were a pill
that cost very little, reduced cardiac deaths by 27%, improved quality of
life, and reduced anxiety and depression, every cardiac patient in
Europe would be expected to take it. There is no such
pill, but taking part in a cardiac rehabilitation programme can provide
all these benefits. In the UK, only a small
number of those in need are offered the chance to take
part.”
Professor Bob Lewin,
European Society of Cardiology, Amsterdam,
2005
Risk of AMI
The chance of a 45
year old female getting to 75 years of age without an AMI is one in
three.
For a 45 year old
male, it is one in two!!
Also -
"Renal disease =
small and large vessel heart disease"
Professor Ian
Meredith, Interventional Cardiologist, MMC, Feb 2007
Smoking - Quiting
smoking is difficult
- Most smokers are
(bio-socially) dependent
- Many use tobacco
in dealing with day to day life - although if provides false
help
- Many smokers
enjoy the experiences from the cigarettes they smoke - some out of
habit
- Smoking is
strongly cued - especially situational - ie if you see someone smoking,
it makes you want to smoke
- Tobacco use
plays various social roles - ie ultimate pick-up, building camaraderie
among groups
Determinants of
dependence
- social/environmental determinants
- habit/conditioned
- biological
determinants
Quit attempts influenced
by:
- Self-efficacy
- dependence
- attitudes to
smoking
- recent
attempts
- plans to
quit
- health
worries
What
works?
- Nicotine
Replacement Therapy (NRT) doubles people's chance of success -
especially if you use higher strength products
- New
tablet called Varenicline - Trade Name: Champix is more
effective than Zyban
- Behavioural programs with Pharmacotherapy
is best - has additive benefits
Only 5% of smokers
contact Quitline whereas 40% of smokers make a quit attempt per
year
Notes from lecture
by Professor Ron Borland
Nigel Gray
Distinguished Fellow in Cancer
Prevention,
Vic Health Centre
for Tobacco Control,
Cancer Control
Research Institute,
The Cancer
Council Victoria,
Time delay to
treatment and mortlaity in AMI
For every 30
minute delay in having coronary artery opened up, there is an increase in
one year mortality by 7.5%
Ref: De Luca G,
Circulation, 2004: 109; 1223 - 25
Vascular
grafts - Types of
Vascular grafts
are classified as either biological or synthetic
a) Two types
of biological:
* autograft: one taken from another site in the patient (eg saphenous vein
graft) * allograft: one taken from another animal of
the same species (also known as homograft)
b) Synthetic:
Dacron graft: manufactured from polytetrafluoethylene
Most common
problems with vascular grafts:
* graft occlusion * graft infection - rare (1 -
2%) * true or false aneurysm at site of
anastomosis * distal embolism
or * erosion into adjacent structures eg
aortic-enteric fistula
below some more did you
knows i will organise one of these days,
1 Did you know....?
Australians with multiple risk factors for cardiovascular
disease
*
Around nine in ten Australian adults had at least one risk
factor * Poor diet and physical inactivity were the
most prevalent risk factors * Regardless of age,
people were most likely to have two risk factors *
People in the most disadvantaged socioeconomic group were more likely to
have three or more risk factors * People who had
more risk factors were also more likely to report even having had a heart
attack, stroke, angina or atherosclerosis –
independent of age and
sex
Ref: 2001 National Health
Survey
2 Did you know...?Atrial
Fibrillation Most common sustained cardiac arrhythmia and a major cause
of illness and death in our community
It is a major cause of
hospital admissions.
AF significantly increases
risk for stroke
Prevalence: Less than 1% in
young adults, but approximately 10% in those aged 80 and
above
Identifiable causes of
AF:
*
Hypertension * Coronary Heart
Disease * Valvular Heart
Disease * Cardiomyopathy/CHF *
Pericarditis * Pulmonary
Embolism * Alcohol excess * No
identifiable cause - also known as "lone AF": 2 - 30% - ?genetic cause -
get a good family history!
Notes from lecture by
A/Professor Diane Fatkin, Molecular Cardiology, Victor Chang Cardiac
Research Institute, Sydney, NSW
3 Did you know....?
Smokefree bars and clubs prompt rise in weekend quitters In the three
months since the July 1 smoking bans, weekend calls to the Victorian
Quitline have jumped by almost 20%, compared with the
number of people calling for
advice on kicking the habit on the weekends in the three months prior to
the bans.
Almost 800 people have
called the Quitline on either Saturday or Sunday in the last three
months.
Media Release, Quit
Victoria, October, 2007
4 Did you know...?
Motivating Behaviour Change Motivation is a state of readiness for
change, rather than a personality trait
Motivating Behaviour
Change
Helping patients achieve
lifestyle change is more difficult than JUST telling them what to do -
success will depend on an interaction between
some or all of these
factors:
* Their
emotions: confidence, self-efficacy, depression, anxiety,
optimism * Their previous experiences of trying to
change – success or failure * Their beliefs,
knowledge and attitudes – causes, cures, safety *
Their skills in change – knowing how to change *
Their environment – smokefree, opportunity to exercise
safely * How many other problems they have to
face
Motivators = all those
forces that encourage patients to change
Notes from Bob Lewin, ACRA
Conference, Hobart, August 2007
5 Did you know...? Greying
popluation "80 percent of people over 65 have three or more chronic
health conditions"
comments by Tony McBride,
Health Issues Centre chief executive
The Age, Nov 9,
2007
Did you know....? Prevention
is better than cure The Australian Institute of Health and Welfare
figures show that federal and state governments in 2005-06 spent $1.4
billion on preventative
health (which includes
immunisations, education and cancer screening) out of a total government
recurrent spending on health of $55.1 billion.
Dr Tony Hobbs, chairman of
the Australian General practice Network says "Take for instance, obesity.
Between 20 and 25 percent of the
population is obese, and
more than half is overweight. If current trends continue, health experts
estimate about 80 percent of adults and a
third of children could be
overweight or obese by 2020. Yet people who are obese can't get a
Medicare-funded referral from a GP to see a
health professional such as
a dietitian to help them lose weight. They can only get one if they have
another chronic condition, such as diabetes.
The policy means people
can't get a Medicare referral to help them lose weight until they have a
more complex and expensive medical
problem".
The Age, Nov 9, 2007 page
8 Did you know....? New Targets for Smoking rates Currently
17.5% of adult Australians smoke - the target is to reduce this rate to
14% by the year 2013
The State Government has
announced an extra $5.5 million for tobacco control
strategies
Quit Victoria will be
doubling their TV advertisements as this medium is clearly the most
effective aid in getting people to stop smoking.
Suzie Stillman, Deputy
Director, Quit Victoria, November, 2007 Did you know...? Urban
myths in Cardiology Urban myths in cardiology
by ESC Congress News
Correspondent: Janet Fricker
HARDLY a week goes by
without a new study linking diet to heart disease. The studies are
enormously contradictory – some show
causative effects, others
protective, and this creates huge confusion. Here our experts guide you
through some of the current urban myths in
cardiology.
Another cup of
coffee?
Different studies have
associated coffee with both cardiovascular risks and benefits. Coffee
contains more than 1000 different biologically
active substances; some
(like caffeine) are detrimental to the heart, while others (like
antioxidants) are protective.
Study design seems to
influence results, explains Ahmed El-Sohemy, Canada Research Chair in
Nutrigenomics (University of Toronto,
Canada). Case-control
studies have shown that increased coffee consumption was associated with
an increased risk of coronary heart
disease (CHD), while
prospective cohort studies have shown either no effect or a protective
effect for moderate intakes. “Such discrepancies
suggest that coffee may have
acute effects on the risk of CHD, which are revealed in case-control
studies, but obscured in cohort studies by
the time lag between
exposure assessment and outcome,” says El-Sohemy.
The method of coffee
preparation appears to be important. Boiled (unfiltered) coffee raises
serum cholesterol levels to a greater extent than
filtered coffee. The
cholesterolraising factors have been identified as the diterpenes,
substances that are extracted by hot water but retained by
filter paper, neatly
explaining why filter coffee does not affect cholesterol. Coffee may
protect against type 2 diabetes, a risk factor for CHD.
Coffee contains the
antioxidant chlorogenic oxide, which can inhibit the glucose-6-phosphatase
system and decrease intestinal absorption of
glucose.
The way the body metabolises
caffeine may affect CHD risk. In a recent study El-Sohemy and colleagues
showed that coffee was associated
with an increased risk of
nonfatal MI among individuals with slow caffeine metabolism, but not among
fast metabolisers. Caffeine is
metabolised by the
polymorphic cytochrome P450 1A2 (CYP1A2) enzyme, and people who are
homozygous for the CYP1A2*1A allele
are "rapid" caffeine
metabolisers, whereas carriers of the variant CYP1A2*1F are "slow"
metabolisers.
Eggs
unscrambled
The popular belief is that
cholesterol in the diet is automatically translated into cholesterol in
the blood, which is then laid down in the coronary
arteries. Since eggs
represent the richest source of dietary cholesterol, with a yolk
containing between 50 and 250 mg cholesterol, they have
taken much of the rap for
the adverse effects of dietary cholesterol. New evidence suggests this
reputation is unjustified.
Studies by Henry Ginsberg in
the 1990s showed that men who ate up to four eggs a day increased their
total serum cholesterol by 0.038
mmol/L per 100 mg of added
dietary cholesterol, and that women increased their total serum
cholesterol by 0.073 mmol/L per 100 mg of
added dietary
cholesterol.
In 1999 researchers from the
Harvard School of Public Health found no relationship between egg
consumption and cardiovascular disease
when they followed 80,000
women for more than 14 years in the Nurses’ Health Study and almost 38,000
men for eight years in the Health
Professionals Follow-up
Study. One egg per day, the authors concluded, had no impact on heart
disease risk.
In addition, since eggs are
low in calories, yet have a high satiety index, they may offer an
effective approach to weight loss.
Many earlier studies showing
links between dietary cholesterol and blood cholesterol were confounded by
the fact that dietary cholesterol
and saturated fat frequently
occur together in the diet, making it difficult to distinguish between
their individual effects.
ed wine or
white?
Regular consumption of red
wine has been suggested as the explanation for the "French paradox",
whereby French people have a relatively
low incidence of coronary
atherosclerosis compared to other Western populations with identical
smoking habits and lifestyles.
A Lancet report by Renaud
and De Lorgeril noted that the annual mortality rate per 100,000
population from CHD was 78 in Toulouse,
France, compared to 348
in Belfast, UK, and 380 in Glasgow, UK, despite similar intakes of
saturated fat. Analysing 17 countries, Renaud and De Lorgeril found that
wine was the only foodstuff
to show a negative correlation with mortality, indicating a protective
effect. When this news appeared on 60
Minutes in the US in 1991,
red wine drinking increased by 44% and some wineries began lobbying for
the right to label their products “health
food”.
Subsequent observational
studies have shown consistent reductions in all-cause mortality among red
wine drinkers. A number of mechanisms
have been suggested - that
alcohol increases HDL cholesterol, that alcohol inhibits platelet
aggregation, and most recently that polyphenols in
red wine activate a receptor
on the surface of platelets, called PECAM-1, which inhibits platelet
aggregation and thus prevents further
thrombus
growth.
“While observational studies
have shown an association, this does not prove cause and effect,” says
Dylan de Lange from the Thrombosis and Haemostasis Laboratory, Utrecht,
the Netherlands. The current debate centres on
whether the “French Paradox”
is because of components of the wine, or the result of confounding
factors, such as the lifestyle of wine
drinkers. Factors other than
alcohol or red wine may have an influence on mortality - red wine
consumers may buy healthier food products,
while the “sick quitter
phenomenon”, where abstainers have a higher all-cause mortality, may
include people who stopped drinking because of
health problems. One study
showed that 27 out of 30 cardiovascular risk factors were more
prominent in abstainers than in consumers of alcohol.
“What’s needed to resolve
the issue is a double-blind placebo controlled trial with solid
end-points, such as MI and death,” says de Lange.
“But how do you blind a
trial in which people have to drink alcohol? It’s easy to distinguish
between a glass of red wine and a glass of grape
juice.” He sees the only way
forward as conducting a trial using polyphenols, “but, before we can do
this trial, issues need to be resolved
around bioavailability,
and the best combinations of polyphenols.”
Omega-3 fatty
acids
Interest in omega-3 fatty
acids was first sparked in the 1970s when studies by Bang and Dyerberg
showed that the Greenland Inuit, who
consumed a diet rich in oily
fish, had an exceptionally low incidence of cardiovascular disease
compared to other populations. These basic
observations about omega-3
fatty acids – a specific type of polyunsaturated fat found in fatty fish
(such as wild salmon, sardines and
mackerel)and plant food
sources (such as flax, walnuts and canola oil) – spawned hundreds of other
studies.
The strongest evidence for a
beneficial effect comes from the Gruppo Italiano per lo Studio della
Sopravvivenza nell’Infarto miocardico
(GISSI)-Prevezione study, in
which 5654 patients with coronary artery disease were randomised to either
omega-3 fatty acids (850 mg/d) or
usual care. After 3.5 years,
those taking the omega-3 fatty acids had experienced a 20% reduction in
overall mortality and a 45% decrease in
risk for sudden cardiac
death. Subsequent metaanalyses have shown a favourable effect of fish
fatty acids on stroke and fatal coronary heart
disease.
Further evidence suggests
omega-3 fats have anti-arrhythmic effects (including reventing atrial
fibrillation), anti-thrombotic actions, anti-
atherogenic effects,
antiinflammatory effects and the ability to lower blood pressure and
improve endothelial function.
However, last year doubts
were cast after the publication of a systematic review by Lee Hooper and
colleagues from the University of East
Anglia (Norwich, UK). The
study – which included 48 randomised control trials and 41 cohort studies
– found no strong evidence for a
reduction in combined
cardiovascular events in patients taking omega-3.
The authors, however,
acknowledged that the inclusion of an observational study by Burr and
co-workers advising 3000 men with stable
angina to eat oily fish or
take fish oil supplements was largely responsible for the net neutral
effect.
A number of explanations
have been offered as to why the angina study produced conflicting results.
“It could be because the very long
follow-up brought out the
harmful effects of methylmercury, a fat soluble toxicant found in oily
fish that is known to increase risks of MI,”
suggests Marika Massaro, a
nutrition researcher from Institute of Clinical Physiology of the
National Council of Research (Italy).
Marianne Geleijnse, a
nutritionist and epidemiologist from Wageningen University Netherlands),
believes that there may also be a biological
explanation since the study
was undertaken in angina patients who may be different from other
patients. She said it was significant that the
study suffered from several
logistical problems and did not differentiate between fish and fish oil
supplements.
To resolve the issue,
Geleijnse and colleagues are undertaking a double-blind andomised
placebo-controlled trial, where coronary patients
are being randomised to
margarine with or without fish oil. In the meantime, people are
recommended to eat at least two servings of oily fish
per week.
In Italy, says Massaro, the
results of GISSI are thought so convincing that omega-3 is now
prescribed as secondary prevention treatment for patients who have
suffered an MI.
Did you know...?
Maintaining successful weight loss Personal contact is best strategy
for maintaining successful weight loss
Regular personal contact
with a health care professional, even by phone, is more effective than
other approaches to long-term maintenance of
a stable body weight after
successful weight loss.
Source: Svetkey, L. et al.
JAMA 2008; 299: 1139-1148. Did you know...? Acute Management of
Chest Pain Acute management of chest pain
·
People experiencing symptoms of an Acute Coronary Syndrome (ACS) should
seek help promptly and activate emergency medical
services.
· The
most important initial need is access to a defibrillator to avoid early
cardiac death resulting from reversible arrhythmias.
·
Aspirin should be given early (ie, by emergency or ambulance personnel)
unless already taken or contraindicated.
·
Oxygen should be given, as well as glyceryl trinitrate and intravenous
morphine as required.
· As a
minimum, medical facilities receiving patients should be given warning of
incoming patients in whom there is a high suspicion of an
ACS — particularly
ST-segment-elevation myocardial infarction (STEMI) — or whose condition is
unstable.
·
Where appropriate, a 12-lead electrocardiogram (ECG) should be taken en
route and transmitted to a medical facility.
·
Where formal protocols are in place, prehospital treatment (including
fibrinolysis in appropriate cases) should be
facilitated.
Ref: Guidelines for the
management of acute coronary syndromes, 2006, National Heart Foundation
and The Cardiac Society of Australia
and New
Zealand
Did you know...?
Exercise and CHD. Exercise can reduce the risk of CHD posed by elevated
BMI, but not eliminate it
Researchers have shown that
the risk of coronary heart disease (CHD) associated with elevated body
mass index (BMI) can be reduced
considerably with the
inclusion of regular physical activity; however, the risk cannot be
eliminated completely, even with high levels of
activity.
It is now well established
that obesity and physical inactivity independently increase the risk of
CHD; however, little is known about the
combined effect of physical
activity and body weight on morbidity and mortality. Weinstein et al.
conducted a prospective cohort study
among a cohort of women to
investigate the relationship of physical activity and BMI to determine if
physical activity can reverse the
deleterious effects of
elevated BMI.
A total of 38,987 women aged
=45 years, who were free of cardiovascular disease, cancer and diabetes at
baseline were included into the
study. Normal weight was
defined as BMI <25, a BMI of 25–29 was deemed overweight, and BMI =30
was defined as obese. Women
who expended in excess of
1000 kilocalories by way of recreational activities in a given week were
defined as ‘physically active’. Six
combined body
weight–physical activity categories were established for analysis. The
main outcome measure was the occurrence of incident
CHD during the follow-up
period (mean follow-up of 10.9 years). Incident CHD referred to a
cardiovascular event including nonfatal
myocardial infarction,
coronary artery bypass graft, percutaneous luminal coronary angioplasty,
or CHD-related death.
During follow-up 948 cases
of incident CHD occurred. As expected, raised BMI and reduced levels of
physical activity were found to
independently increase the
risk of CHD.
Importantly, the results
showed that physical activity did attenuate the risk of CHD. The results
strongly supported the current guidelines
which recommend at least 30
minutes of moderate activity per day. Furthermore, the study results
suggested that more than 30 minutes of
physical activity per day
could further reduce the risk of CHD. However, even extremely high levels
of exercise could not completely
eliminate the excess risk of
CHD among overweight or obese women without concurrent weight
loss.
The authors concluded that
the risk of CHD associated with BMI in CHD is significantly reduced by the
inclusion of physical activity.
“Regardless of body weight,
these data highlight the importance of counselling all women to
participate in increasing amounts of regular
physical activity and
maintaining a healthy weight to reduce the risk of CHD,” they
stated.
Reference
Weinstein, A. Sesso, H. et
al. 2008, ‘The joint effects of physical activity and body mass index on
coronary heart disease risk in women’
Arch Intern Med; 168:
884–890.
Did you know...? Fish
Oils About five years ago, the American Heart Association Nutrition
Committee issued its position statement that all patients with CHD ought
to
have the equivalent of 1 g
of combined EPA and DHA, i.e. a fish-oil supplement. The National Heart
Foundation of Australia will later this
year be disseminating
detailed recommendations and a literature review supporting a similar
statement.
In addition, fish oil is
effective in lowering triglycerides with a similar efficacy to fibrates.
Fish oil decreases risk of sudden death following a
myocardial infarction and,
at high dose, further infarctions.. Sterol-enriched foods and foods high
in fibre lower LDL effectively.
Ref: Professor David
Colquhoun, Associate Professor of Medicine, University of Queensland, and
Cardiologist at Wesley Medical Centre as
published in Complimentary
Medicine, March/April 2008 pg 5
Did you know....?
Coronary Artery Spasm Coronary Artery Spasm
* First
description by Prinzmetal et al. in 1959 *
"exaggerated contractile response of epicardial coronary artery smooth
muscle to various stimuli" * 60% superimposed on
fixed coronary lesions
Clinical
characteristics:
* younger
age than obstructive CAD * Japanese > Caucasian
(diffuse and multi-vessel in Japanese v focal in
Caucasians) * Smoker/cocaine *
associations: Raynaud's, Migraine, Kawasaki *
episodes occur at rest and between midnight and early
morning * exercise and hyperventilation can be
precipitants * ECG: ST segment elevation
characteristic +/- wave changes over days *
Arrhythmias common (20 - 50%)
o # LAD -
VT,
o #RCA - heart block
Notes by Dr Andrew Ajani,
Cardiologist, Director of CCU, RMH
Did you know...? How
to correctly measure a standard drink The recent National Drug Research
Institute study on alcohol consumption revealed that wine drinkers were
consuming up to twice as much
alcohol as they
thought.
Drinkers were asked to
estimate the number of standard drinks they consumed in a week and were
then allowed to pour their "normal" drink.
Participants underestimated
the measure anywhere from 10% to 100%.
In response, the Federal
Government is reportedly introducing mandatory standard drink logos and
education.
So, what is a standard
drink?
A standard drink contains 10
grams of pure alcohol or ethanol. Depending on the level of alcohol, a
standard drink can vary, but for most
table wines a standard drink
is somewhere around 100-12 millilitres.
A standard drink, as seen on
wine bottles, is calculated on the size of the container and the
percentage of alcohol.
A 750-mililitre bottle of
wine with 12.5% alcohol is calculated this: 0.75 x 12.5 x 0.789 (specific
gravity of ethanol) = 7.39 standard drinks
(or 7.4 when rounded
off) Did you know...? Rates of smoking and education
level Rates of Smoking and education level
Australians >18 years of
age who smoke:
*
Finished tertiary education: 11.8% * Year 12/some
tertiary education: 18.7% * Year 11 or less:
21%
Also,
* Smoking
is an indicator of, and possible cause of, downward social
mobility * However, those from a low socio-economic
status (SES) have not shown a disadvantage in the ability to
quit
Smoking causes (in middle
age) 1/3 of all death:
* 20%
among high SES, and * ~40% among low
SES
Sianpush et al (2006) Vic
Health Centre for Tobacco Control
notes from Ron Borland
PhD
Vic Heatlh Centre for
Tobacco Control
Did you know....?
Cultural Diversity in Victoria Cultural Diversity in
Victoria
* 44% of
Victorians were either born overseas or have at least one parent born
overseas * 20% of Victorians speak a language other
than English at home * One in four migrants to
Australia live in Victoria * One in five University
students is an international student (in 2006) * We
speak more than 150 languages and practise more than 100
faiths.
Population Diversity in
Local Councils, 2006 Census Did you know...? ICD - shocks while
driving Very low risk from ICD shocks while driving
Patients with an Implantable
Cardioverter Defibrillator (ICD) have a very low risk of receiving a shock
while driving and only one in 25,000
chance of a shock in the
subsequent hour, according to data from the Triggers of Ventricular
Arrhythmias (TOVA) study
Reference: Albert C et al,
Journal of the American College of Cardiology, 2007; 50: 2233 –
2240
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